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Kinetic Recognition of AT‐Rich DNA by Ruthenium Complexes
Author(s) -
Nordell Pär,
Westerlund Fredrik,
Wilhelmsson L. Marcus,
Nordén Bengt,
Lincoln Per
Publication year - 2007
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200604294
Subject(s) - ruthenium , intercalation (chemistry) , dna , threading (protein sequence) , selectivity , chemistry , base pair , kinetic energy , sequence (biology) , kinetics , crystallography , stereochemistry , inorganic chemistry , biochemistry , catalysis , protein structure , physics , quantum mechanics
Finding AT tracts : High selectivity for long AT sequences can be attained through kinetically controlled DNA threading intercalation by binuclear ruthenium(II) complexes (see picture). The rate of intercalation is strongly correlated to the number of consecutive AT base pairs and is up to 2500‐times higher with poly(dAdT) 2 than with mixed‐sequence DNA.