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Structure and Total Synthesis of Lysobactin (Katanosin B)
Author(s) -
von Nussbaum Franz,
Anlauf Sonja,
BenetBuchholz Jordi,
Häbich Dieter,
Köbberling Johannes,
Musza László,
Telser Joachim,
RübsamenWaigmann Helga,
Brunner Nina A.
Publication year - 2007
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200604232
Subject(s) - antibiotics , total synthesis , computer science , chemistry , combinatorial chemistry , stereochemistry , biochemistry
Tackle‐resistant bacteria : Determination of the 3D structure of the antibiotic lysobactin has led to its total synthesis and resulted in a high‐yielding macrolactamization step. The minimal use of protecting groups allowed preorganization of the side chains to steer the cyclization. Thus, a new chemical route has been developed in the search for innovative antibiotic lead structures.