Overcoming Thermodynamic and Kinetic Limitations of Aldolase‐Catalyzed Reactions by Applying Multienzymatic Dynamic Kinetic Asymmetric Transformations | Zendy

Steinreiber Johannes | Zendy; Schürmann Martin | Zendy; Wolberg Michael | Zendy; van Assema Friso | Zendy; Reisinger Christoph | Zendy; Fesko Kateryna | Zendy; Mink Daniel | Zendy; Griengl Herfried | Zendy

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Overcoming Thermodynamic and Kinetic Limitations of Aldolase‐Catalyzed Reactions by Applying Multienzymatic Dynamic Kinetic Asymmetric Transformations

Author(s) -

Steinreiber Johannes,

Schürmann Martin,

Wolberg Michael,

van Assema Friso,

Reisinger Christoph,

Fesko Kateryna,

Mink Daniel,

Griengl Herfried

Publication year - 2007

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.200604142

Subject(s) - aldolase a , kinetic energy , catalysis , thermodynamics , chemistry , computational chemistry , organic chemistry , enzyme , physics , quantum mechanics

Dynamic and successful : The asymmetric synthesis of 2‐amino‐1‐phenylethanol was achieved by aminomethylation of benzaldehyde in the presence of the two enzymes L ‐threonine aldolase and L ‐tyrosine decarboxylase in a novel one‐pot, two‐enzyme process (see scheme). A modified method with three enzymes led to the enantioenriched amino alcohol in very high yield.

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