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Overcoming Thermodynamic and Kinetic Limitations of Aldolase‐Catalyzed Reactions by Applying Multienzymatic Dynamic Kinetic Asymmetric Transformations
Author(s) -
Steinreiber Johannes,
Schürmann Martin,
Wolberg Michael,
van Assema Friso,
Reisinger Christoph,
Fesko Kateryna,
Mink Daniel,
Griengl Herfried
Publication year - 2007
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200604142
Subject(s) - aldolase a , kinetic energy , catalysis , thermodynamics , chemistry , computational chemistry , organic chemistry , enzyme , physics , quantum mechanics
Dynamic and successful : The asymmetric synthesis of 2‐amino‐1‐phenylethanol was achieved by aminomethylation of benzaldehyde in the presence of the two enzymes L ‐threonine aldolase and L ‐tyrosine decarboxylase in a novel one‐pot, two‐enzyme process (see scheme). A modified method with three enzymes led to the enantioenriched amino alcohol in very high yield.