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Fluorescence‐Lifetime Imaging of DNA–Dye Interactions within Continuous‐Flow Microfluidic Systems
Author(s) -
Benninger Richard K. P.,
Hofmann Oliver,
Önfelt Björn,
Munro Ian,
Dunsby Chris,
Davis Daniel M.,
Neil Mark A. A.,
French Paul M. W.,
de Mello Andrew J.
Publication year - 2007
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200604112
Subject(s) - microfluidics , fluorescence , continuous flow , modality (human–computer interaction) , fluorescence lifetime imaging microscopy , computer science , dna , nanotechnology , information flow , channel (broadcasting) , biological system , flow (mathematics) , superresolution , chemistry , materials science , physics , image (mathematics) , artificial intelligence , biology , optics , engineering , biochemical engineering , telecommunications , biochemistry , linguistics , philosophy , mechanics
Light across the channel : The utility of time‐resolved fluorescence imaging as a detection modality for microfluidic systems has been extended by a study of DNA–dye binding interactions. The combination of time‐resolved fluorescence imaging and continuous‐flow microfluidics provides a powerful route to the resolution and quantification of multistate biological systems with precise spatial and temporal reaction control.