Premium
Surface‐Chemistry Control To Silence Gene Expression in Drosophila Schneider 2 Cells through RNA Interference
Author(s) -
Chan Eugene W. L.,
Yousaf Muhammad N.
Publication year - 2007
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200604079
Subject(s) - rna interference , silence , gene silencing , gene , rna , rna silencing , microbiology and biotechnology , gene expression , population , gtpase , interference (communication) , cell , biology , chemistry , computational biology , genetics , computer science , physics , telecommunications , sociology , channel (broadcasting) , demography , acoustics
A good combination : RNA interference (RNAi) technology combined with surface chemistry can be used to control RNAi‐mediated gene silencing in Drosophila Schneider 2 (S2) cells patterned on tailored self‐assembled monolayers of alkanethiolates on gold. The cell population and not the cell confluence was shown to be critical for the effectiveness of RNAi Rho GTPase.