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Total Synthesis of Phalarine
Author(s) -
Li Chaomin,
Chan Collin,
Heimann Annekatrin C.,
Danishefsky Samuel J.
Publication year - 2007
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200604072
Subject(s) - total synthesis , product (mathematics) , oxindole , computer science , natural product , content (measure theory) , scheme (mathematics) , chemistry , stereochemistry , organic chemistry , mathematics , mathematical analysis , geometry , catalysis
End of the expedition … for now : Completion of the first total synthesis of phalarine from an advanced rearrangement product brought up interesting obstacles to overcome. Use of the Gassman oxindole synthesis and subsequent manipulations led to the racemic natural product (see scheme, Ts=toluene‐4‐sulfonyl).