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Total Synthesis of Rapamycin
Author(s) -
Maddess Matthew L.,
Tackett Miles N.,
Watanabe Hidenori,
Brennan Paul E.,
Spilling Christopher D.,
Scott James S.,
Osborn David P.,
Ley Steven V.
Publication year - 2007
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200604053
Subject(s) - natural product , catechol , cancer chemotherapy , chemistry , relevance (law) , total synthesis , computational biology , cancer research , stereochemistry , cancer , biology , biochemistry , genetics , political science , law
Rapamycin synthesis all wrapped up : A new convergent synthesis of rapamycin ( 1 ) is reported that involves a macroetherification/catechol tethering strategy for construction of the macrocyclic core of this intriguing natural product. Other studies on this commercialized potent immunosuppressant delineate new cell signaling pathways of relevance to cancer chemotherapy.