High Enantioselectivity Is Induced by a Single Monodentate Phosphoramidite Ligand in Iridium‐Catalyzed Asymmetric Hydrogenation | Zendy

Giacomina Francesca | Zendy; Meetsma Auke | Zendy; Panella Lavinia | Zendy; Lefort Laurent | Zendy; de Vries André H. M. | Zendy; de Vries Johannes G. | Zendy

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High Enantioselectivity Is Induced by a Single Monodentate Phosphoramidite Ligand in Iridium‐Catalyzed Asymmetric Hydrogenation

Author(s) -

Giacomina Francesca,

Meetsma Auke,

Panella Lavinia,

Lefort Laurent,

de Vries André H. M.,

de Vries Johannes G.

Publication year - 2007

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.200603930

Subject(s) - phosphoramidite , iridium , enantioselective synthesis , asymmetric hydrogenation , denticity , chemistry , transfer hydrogenation , ligand (biochemistry) , combinatorial chemistry , catalysis , noyori asymmetric hydrogenation , medicinal chemistry , organic chemistry , metal , ruthenium , dna , biochemistry , receptor , oligonucleotide

The Full Monty? Stripping a catalyst down to its bare essentials gives a neutral iridium complex containing only one monodentate phosphoramidite ligand that is an efficient catalyst for the enantioselective hydrogenation of α‐dehydroamino acids (see picture).

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