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High Enantioselectivity Is Induced by a Single Monodentate Phosphoramidite Ligand in Iridium‐Catalyzed Asymmetric Hydrogenation
Author(s) -
Giacomina Francesca,
Meetsma Auke,
Panella Lavinia,
Lefort Laurent,
de Vries André H. M.,
de Vries Johannes G.
Publication year - 2007
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200603930
Subject(s) - phosphoramidite , iridium , enantioselective synthesis , asymmetric hydrogenation , denticity , chemistry , transfer hydrogenation , ligand (biochemistry) , combinatorial chemistry , catalysis , noyori asymmetric hydrogenation , medicinal chemistry , organic chemistry , metal , ruthenium , dna , biochemistry , receptor , oligonucleotide
The Full Monty? Stripping a catalyst down to its bare essentials gives a neutral iridium complex containing only one monodentate phosphoramidite ligand that is an efficient catalyst for the enantioselective hydrogenation of α‐dehydroamino acids (see picture).