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Total Synthesis of Platensimycin
Author(s) -
Nicolaou K. C.,
Li Ang,
Edmonds David J.
Publication year - 2006
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200603892
Subject(s) - natural product , total synthesis , bacteria , chemistry , combinatorial chemistry , computational biology , biology , stereochemistry , genetics
Beat the superbugs : The newly discovered antibiotic platensimycin ( 1 ) promises to combat current drug‐resistant infections. The natural product shows potent activity against Gram‐positive bacteria and contains a novel molecular architecture. The total synthesis of this intriguing natural product that opens the way to a variety of otherwise inaccessible analogues has now been achieved (calculated structure shown on the right).