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DNA‐Controlled Reversible Switching of Peptide Conformation and Bioactivity
Author(s) -
Röglin Lars,
Ahmadian Mohammad R.,
Seitz Oliver
Publication year - 2007
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200603889
Subject(s) - peptide , dna , peptide nucleic acid , conjugate , nucleic acid , chemistry , computational biology , biochemistry , microbiology and biotechnology , biology , mathematical analysis , mathematics
A DNA switch: Hybridization with DNA controls the conformation of a peptide nucleic acid (PNA)–peptide conjugate. This reversible process can activate (see scheme) or deactivate the binding propensity of the peptide for a protein target involved in cellular signal transduction.