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A Mild Chemically Cleavable Linker System for Functional Proteomic Applications
Author(s) -
Verhelst Steven H. L.,
Fonović Marko,
Bogyo Matthew
Publication year - 2007
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200603811
Subject(s) - linker , cleavage (geology) , proteome , chemistry , combinatorial chemistry , small molecule , biophysics , biochemistry , computational biology , biology , computer science , paleontology , fracture (geology) , operating system
An amicable split : Small‐molecule probes can be applied for the enrichment of specific protein targets from a complex proteome. A cleavable linker system, which prevents the release of unwanted, nonspecifically bound proteins, can be used for a very mild and highly selective cleavage of probe‐labeled proteins.