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Functional Architecture of HCV IRES Domain II Stabilized by Divalent Metal Ions in the Crystal and in Solution
Author(s) -
Dibrov Sergey M.,
JohnstonCox Hillary,
Weng YiHsin,
Hermann Thomas
Publication year - 2006
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200603807
Subject(s) - divalent , divalent metal , rna , metal ions in aqueous solution , domain (mathematical analysis) , metal , ion , chemistry , crystallography , crystal (programming language) , crystal structure , nanotechnology , materials science , computational biology , virology , physics , computer science , biology , biochemistry , gene , mathematics , organic chemistry , mathematical analysis , programming language
Around the bend : A right‐angled bend in the RNA of the hepatitis C virus is stabilized by a core of divalent metal ions (shown as green and violet spheres). Crystal‐structure analysis and fluorescence labeling have been used to investigate the structure and metal‐ion‐dependent stabilization of the RNA domain that plays a key role in viral protein synthesis.