Premium
Alcohols as Electrophiles in CC Bond‐Forming Reactions: The Hydrogen Autotransfer Process
Author(s) -
Guillena Gabriela,
Ramón Diego J.,
Yus Miguel
Publication year - 2007
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200603794
Subject(s) - electrophile , nucleophile , catalysis , hydrogen , chemistry , alkylation , combinatorial chemistry , organic chemistry
The hydrogen autotransfer process involves an initial oxidative hydrogen elimination, followed by different types of reactions, and is completed with a reductive hydrogen addition to give the final product. The sequence allows the alkylation of different nucleophilic agents using environmentally benign alcohols as electrophiles, mild conditions, and soft bases, with water produced as the only waste material. Recent examples of modulating the organometallic catalyst have also lent themselves to expansion of the range of available substrates, as described in this Minireview.