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Ligand Bridging of the DNA Holliday Junction: Molecular Recognition of a Stacked‐X Four‐Way Junction by a Small Molecule
Author(s) -
Brogden Anna L.,
Hopcroft Nicholas H.,
Searcey Mark,
Cardin Christine J.
Publication year - 2007
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200603760
Subject(s) - holliday junction , chromophore , dna , acridine , molecule , chemistry , ligand (biochemistry) , stereochemistry , crystallography , biophysics , computational biology , biology , biochemistry , photochemistry , homologous recombination , receptor , organic chemistry
Planning a Holliday : A new mode of binding to a stacked‐X, four‐way Holliday junction is described in which a chromophore molecule binds across the center of the junction and two adenine residues are replaced by the acridine chromophores at either side of the crossover. This binding mode is specific for the Holliday junction and does not cause unwinding of the DNA helices.