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Heterogeneous Copper‐in‐Charcoal‐Catalyzed Click Chemistry
Author(s) -
Lipshutz Bruce H.,
Taft Benjamin R.
Publication year - 2006
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200603726
Subject(s) - cycloaddition , charcoal , click chemistry , copper , catalysis , chemistry , adduct , selectivity , moisture , activated charcoal , organic chemistry , combinatorial chemistry , adsorption
Click here for Cu/C : Copper‐in‐charcoal (Cu/C) is an active catalyst for effecting click reactions between organic azides and 1‐alkynes. Rates of cycloaddition are increased dramatically when carried out in the presence of Et 3 N or using microwave assistance. There is no sensitivity to air or moisture, and the catalyst can be recycled several times without loss of activity or selectivity for the 1,4‐adduct.