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Macrocyclic Ferrocenyl–Bisimidazoline Palladacycle Dimers as Highly Active and Enantioselective Catalysts for the Aza‐Claisen Rearrangement of Z ‐Configured N ‐ para ‐Methoxyphenyl Trifluoroacetimidates
Author(s) -
Jautze Sascha,
Seiler Paul,
Peters René
Publication year - 2007
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200603568
Subject(s) - enantioselective synthesis , catalysis , ferrocene , chemistry , toluene , combinatorial chemistry , sulfonyl , stereochemistry , medicinal chemistry , organic chemistry , alkyl , electrode , electrochemistry
In just four steps from ferrocene , macrocyclic ferrocenyl bispalladacyles have been synthesized by using a diastereoselective biscyclopalladation reaction as the key step. The complexes not only possess a fascinating structure but are also the first highly active catalysts for the title reaction (see scheme), requiring as little as 0.1 mol % of catalyst for most of the substrates. Ts=toluene‐4‐sulfonyl.