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Highly Enantioselective Hydrosilylation/Cyclization of 1,6‐Enynes Catalyzed by Rhodium(I) Complexes of Spiro Diphosphines
Author(s) -
Fan BaoMin,
Xie JianHua,
Li Shen,
Wang LiXin,
Zhou QiLin
Publication year - 2007
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200603533
Subject(s) - hydrosilylation , enantioselective synthesis , diphosphines , rhodium , cyclopentane , catalysis , chemistry , hydroformylation , silanes , pyrrolidine , ligand (biochemistry) , optically active , organic chemistry , medicinal chemistry , combinatorial chemistry , biochemistry , receptor , silane
Highly enantioselective synthesis : The rhodium(I) complex of the chiral ligand SDP is successfully used as a catalyst for the hydrosilylation/cyclization of 1,6‐enynes with silanes. Under the optimized reaction conditions, optically active silylalkenes containing cyclopentane or pyrrolidine rings are obtained in good yields with excellent enantioselectivities (see scheme). DCE=1,2‐dichloroethane