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A Site‐ and Stereoselective Intermolecular Alkene–Alkyne Coupling Process
Author(s) -
Reichard Holly A.,
Micalizio Glenn C.
Publication year - 2007
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200603515
Subject(s) - alkene , alkyne , stereoselectivity , intermolecular force , coupling (piping) , chemistry , stereochemistry , materials science , molecule , organic chemistry , catalysis , metallurgy
Ti‐ght union : A highly regio‐ and stereoselective bimolecular coupling reaction is described for the union of substituted, unactivated olefins and internal alkynes (see scheme). The titanium‐mediated coupling reaction proceeds with CC bond formation occurring distal to a pendent hydroxy group.