Premium
Mild Electrophilic Trifluoromethylation of Carbon‐ and Sulfur‐Centered Nucleophiles by a Hypervalent Iodine(III)–CF 3 Reagent
Author(s) -
Kieltsch Iris,
Eisenberger Patrick,
Togni Antonio
Publication year - 2007
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200603497
Subject(s) - hypervalent molecule , trifluoromethylation , nucleophile , electrophile , reagent , sulfur , chemistry , iodine , carbon fibers , iodine compounds , organic chemistry , alkyl , catalysis , materials science , trifluoromethyl , composite number , composite material
Inexpensive, recyclable, and activable : these are the features of a new mild electrophilic trifluoromethylation reagent that can be used to transfer a CF 3 group to C‐centered nucleophiles, such as β‐keto esters and α‐nitro esters, and to S‐centered nucleophiles (see scheme).