Use of Fluorescence Sensors To Determine that 2‐Deoxyribonolactone Is the Major Alkali‐Labile Deoxyribose Lesion Produced in Oxidatively Damaged DNA | Zendy

Xue Liang | Zendy; Greenberg Marc M. | Zendy

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Use of Fluorescence Sensors To Determine that 2‐Deoxyribonolactone Is the Major Alkali‐Labile Deoxyribose Lesion Produced in Oxidatively Damaged DNA

Author(s) -

Xue Liang,

Greenberg Marc M.

Publication year - 2007

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.200603454

Subject(s) - deoxyribose , dna , fluorescence , chemistry , alkali metal , dna damage , lesion , radiolysis , biopolymer , biophysics , biochemistry , organic chemistry , biology , radical , medicine , pathology , physics , quantum mechanics , polymer

Throwing light on lesions : DNA oxidation is a ubiquitous but potentially dangerous process that produces a variety of structural modifications in the biopolymer. One modified unit, 2‐deoxyribonolactone ( L ), produces cross‐links with DNA repair proteins and is mutagenic. Selective fluorescence sensors (e.g. 1 ) show that L is the major alkali‐labile deoxyribose lesion produced in DNA exposed to γ radiolysis.

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