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Use of Fluorescence Sensors To Determine that 2‐Deoxyribonolactone Is the Major Alkali‐Labile Deoxyribose Lesion Produced in Oxidatively Damaged DNA
Author(s) -
Xue Liang,
Greenberg Marc M.
Publication year - 2007
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200603454
Subject(s) - deoxyribose , dna , fluorescence , chemistry , alkali metal , dna damage , lesion , radiolysis , biopolymer , biophysics , biochemistry , organic chemistry , biology , radical , medicine , pathology , physics , quantum mechanics , polymer
Throwing light on lesions : DNA oxidation is a ubiquitous but potentially dangerous process that produces a variety of structural modifications in the biopolymer. One modified unit, 2‐deoxyribonolactone ( L ), produces cross‐links with DNA repair proteins and is mutagenic. Selective fluorescence sensors (e.g. 1 ) show that L is the major alkali‐labile deoxyribose lesion produced in DNA exposed to γ radiolysis.