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Organocatalytic One‐Pot Asymmetric Synthesis of Functionalized Tricyclic Carbon Frameworks from a Triple‐Cascade/Diels–Alder Sequence
Author(s) -
Enders Dieter,
Hüttl Matthias R. M.,
Runsink Jan,
Raabe Gerhard,
Wendt Bianca
Publication year - 2007
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200603434
Subject(s) - intramolecular force , stereocenter , domino , tricyclic , sequence (biology) , chemistry , stereochemistry , diels–alder reaction , combinatorial chemistry , organic chemistry , enantioselective synthesis , catalysis , biochemistry
Hitting the teens! Five CC bonds and eight stereocenters were formed in a one‐pot asymmetric multicomponent domino reaction, which led to the functionalized tricyclic diterpenoid‐type core structures (see scheme, IMDA=intramolecular Diels–Alder reaction).