Premium
Is the Ferric Hydroperoxy Species Responsible for Sulfur Oxidation in Cytochrome P450s?
Author(s) -
Cryle Max J.,
De Voss James J.
Publication year - 2006
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200603411
Subject(s) - sulfur , ferric , chemistry , cytochrome , organic chemistry , enzyme
Not the ferryl oxidant? The oxidation of thiafatty acids by P450 BM3 (CYP102A1) was shown to be consistent with oxidation by the ferric hydroperoxy species (Cpd 0) rather than the expected ferryl species (Cpd 1). This is the first indication that sulfur oxidation in a wildtype P450 occurs via the hydroperoxy species.