A Solid‐Phase Route to  18 F‐Labeled Tracers, Exemplified by the Synthesis of [ 18 F]2‐Fluoro‐2‐deoxy‐ D ‐glucose | Zendy

Brown Lynda J. | Zendy; Bouvet Denis R. | Zendy; Champion Sue | Zendy; Gibson Alex M. | Zendy; Hu Yulai | Zendy; Jackson Alex | Zendy; Khan Imtiaz | Zendy; Ma Nianchun | Zendy; Millot Nicholas | Zendy; Wadsworth Harry | Zendy; Brown Richard C. D. | Zendy

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A Solid‐Phase Route to 18 F‐Labeled Tracers, Exemplified by the Synthesis of [ 18 F]2‐Fluoro‐2‐deoxy‐ D ‐glucose

Author(s) -

Brown Lynda J.,

Bouvet Denis R.,

Champion Sue,

Gibson Alex M.,

Hu Yulai,

Jackson Alex,

Khan Imtiaz,

Ma Nianchun,

Millot Nicholas,

Wadsworth Harry,

Brown Richard C. D.

Publication year - 2007

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.200603394

Subject(s) - yield (engineering) , linker , fluoride , sulfonate , chemistry , solid phase synthesis , phase (matter) , radiochemistry , nuclear chemistry , combinatorial chemistry , inorganic chemistry , materials science , organic chemistry , biochemistry , computer science , peptide , sodium , metallurgy , operating system

Scintillating synthesis : 18 F‐Containing radiopharmaceuticals can be prepared by using [ 18 F]fluoride ions to displace a sulfonate linker and release a radiotracer from a solid support (see scheme; EOM=ethoxymethyl). The method has allowed the synthesis of the widely used imaging agent [ 18 F]fluoro‐2‐deoxy‐ D ‐glucose in good radiochemical yield and with high chemical purity.

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