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A Solid‐Phase Route to 18 F‐Labeled Tracers, Exemplified by the Synthesis of [ 18 F]2‐Fluoro‐2‐deoxy‐ D ‐glucose
Author(s) -
Brown Lynda J.,
Bouvet Denis R.,
Champion Sue,
Gibson Alex M.,
Hu Yulai,
Jackson Alex,
Khan Imtiaz,
Ma Nianchun,
Millot Nicholas,
Wadsworth Harry,
Brown Richard C. D.
Publication year - 2007
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200603394
Subject(s) - yield (engineering) , linker , fluoride , sulfonate , chemistry , solid phase synthesis , phase (matter) , radiochemistry , nuclear chemistry , combinatorial chemistry , inorganic chemistry , materials science , organic chemistry , biochemistry , computer science , peptide , sodium , metallurgy , operating system
Scintillating synthesis : 18 F‐Containing radiopharmaceuticals can be prepared by using [ 18 F]fluoride ions to displace a sulfonate linker and release a radiotracer from a solid support (see scheme; EOM=ethoxymethyl). The method has allowed the synthesis of the widely used imaging agent [ 18 F]fluoro‐2‐deoxy‐ D ‐glucose in good radiochemical yield and with high chemical purity.