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Single‐Molecule Protein Encapsulation in a Rigid DNA Cage
Author(s) -
Erben Christoph M.,
Goodman Russell P.,
Turberfield Andrew J.
Publication year - 2006
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200603392
Subject(s) - tetrahedron , dna , cage , crystallography , molecule , cytochrome c , chemistry , physics , nanotechnology , computer science , materials science , combinatorics , biochemistry , mathematics , quantum mechanics , mitochondrion
Behind bars : A single molecule of the protein cytochrome c has been incarcerated within a rigid tetrahedral DNA cage (see picture). The central cavity is estimated to be large enough to accommodate a sphere of approximately 2.6 nm in radius, such as a 60‐kDa globular protein ( M r of cytochrome c : 12.4 kDa). The finding demonstrates the potential of DNA containers as a new kind of drug‐delivery system.