Single‐Molecule Protein Encapsulation in a Rigid DNA Cage | Zendy

Erben Christoph M. | Zendy; Goodman Russell P. | Zendy; Turberfield Andrew J. | Zendy

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Single‐Molecule Protein Encapsulation in a Rigid DNA Cage

Author(s) -

Erben Christoph M.,

Goodman Russell P.,

Turberfield Andrew J.

Publication year - 2006

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.200603392

Subject(s) - tetrahedron , dna , cage , crystallography , molecule , cytochrome c , chemistry , physics , nanotechnology , computer science , materials science , combinatorics , biochemistry , mathematics , quantum mechanics , mitochondrion

Behind bars : A single molecule of the protein cytochrome c has been incarcerated within a rigid tetrahedral DNA cage (see picture). The central cavity is estimated to be large enough to accommodate a sphere of approximately 2.6 nm in radius, such as a 60‐kDa globular protein ( M r of cytochrome c : 12.4 kDa). The finding demonstrates the potential of DNA containers as a new kind of drug‐delivery system.

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