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Chemodosimeter for Cu II Detection Based on Cyclic Peptide Nucleic Acids
Author(s) -
Kovács János,
Rödler Thomas,
Mokhir Andriy
Publication year - 2006
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200603391
Subject(s) - nucleic acid , peptide nucleic acid , linker , dna , rna , chemistry , peptide , copper , combinatorial chemistry , transformation (genetics) , ion , cyclic peptide , biochemistry , computer science , organic chemistry , gene , operating system
Copper‐sensitive cycle : A cyclic peptide nucleic acid (PNA) that does not bind DNA and RNA can be prepared by placing an optimized linker between the termini. Cu II ions, but not other tested metal ions, catalyze the transformation of the cyclic PNA into the linear PNA, which is a strong binder of nucleic acids (see picture). This effect is used for the fluorimetric detection of Cu II . ssDNA=single‐stranded DNA