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Origin of Spectral Tuning in Rhodopsin—It Is Not the Binding Pocket
Author(s) -
Sekharan Sivakumar,
Sugihara Minoru,
Buss Volker
Publication year - 2006
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200603306
Subject(s) - rhodopsin , protonation , counterion , visual pigments , schiff base , chemistry , retinal , crystallography , photochemistry , biophysics , ion , biology , biochemistry , organic chemistry
The counterion , not the binding pocket, shifts the absorption of the protonated Schiff base of 11‐ cis ‐retinal into the visible region. This conclusion was drawn from high‐level CASPT2 calculations on the visual pigment rhodopsin (the optimized structure of the binding pocket is shown).