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A Network of Coiled‐Coil Associations Derived from Synthetic GCN4 Leucine‐Zipper Arrays
Author(s) -
Portwich Michael,
Keller Sandro,
Strauss Holger M.,
Mahrenholz Carsten C.,
Kretzschmar Ines,
Kramer Achim,
Volkmer Rudolf
Publication year - 2007
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200603246
Subject(s) - coiled coil , leucine zipper , heptad repeat , zipper , computational biology , sequence (biology) , association (psychology) , computer science , monomer , biology , crystallography , chemistry , peptide sequence , biophysics , biochemistry , algorithm , gene , polymer , philosophy , epistemology , organic chemistry
Two is better than one : Coiled‐coil sequence motifs are versatile protein–protein interaction modules. Single and double substitutions of the GCN4 coiled coil ( 1, 2 , and 3 ) showed that the core positions a and d in the third heptad act as a switch for the transition from the native homodimeric to homotrimeric structures. This creates a synthetic three‐membered association network with monomeric, homotrimeric, and heterodimeric coiled‐coil states.