A Network of Coiled‐Coil Associations Derived from Synthetic GCN4 Leucine‐Zipper Arrays | Zendy

Portwich Michael | Zendy; Keller Sandro | Zendy; Strauss Holger M. | Zendy; Mahrenholz Carsten C. | Zendy; Kretzschmar Ines | Zendy; Kramer Achim | Zendy; Volkmer Rudolf | Zendy

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A Network of Coiled‐Coil Associations Derived from Synthetic GCN4 Leucine‐Zipper Arrays

Author(s) -

Portwich Michael,

Keller Sandro,

Strauss Holger M.,

Mahrenholz Carsten C.,

Kretzschmar Ines,

Kramer Achim,

Volkmer Rudolf

Publication year - 2007

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.200603246

Subject(s) - coiled coil , leucine zipper , heptad repeat , zipper , computational biology , sequence (biology) , association (psychology) , computer science , monomer , biology , crystallography , chemistry , peptide sequence , biophysics , biochemistry , algorithm , gene , polymer , philosophy , epistemology , organic chemistry

Two is better than one : Coiled‐coil sequence motifs are versatile protein–protein interaction modules. Single and double substitutions of the GCN4 coiled coil ( 1, 2 , and 3 ) showed that the core positions a and d in the third heptad act as a switch for the transition from the native homodimeric to homotrimeric structures. This creates a synthetic three‐membered association network with monomeric, homotrimeric, and heterodimeric coiled‐coil states.

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