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Designing a Cocrystal of γ‐Amino Butyric Acid
Author(s) -
Wenger Mazal,
Bernstein Joel
Publication year - 2006
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200603241
Subject(s) - synthon , cocrystal , supramolecular chemistry , hydrogen bond , notation , butyric acid , chemistry , computer science , molecule , combinatorial chemistry , stereochemistry , mathematics , organic chemistry , arithmetic
It takes two : The possibility of developing a strategy for the controlled preparation of cocrystals (see picture) with a predesigned structure is demonstrated. It relies on recognizing and utilizing a specific hydrogen‐bond pattern, defined in graph‐set notation ( ${{{\rm {\rm R}}{{2\hfill \atop 4\hfill}}}}$ (8)), as a supramolecular synthon for the systematic generation of individual four‐molecule clusters.