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Asymmetric Organocatalytic Domino Reactions
Author(s) -
Enders Dieter,
Grondal Christoph,
Hüttl Matthias R. M.
Publication year - 2007
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200603129
Subject(s) - domino , domino effect , computer science , organocatalysis , chemistry , combinatorial chemistry , enantioselective synthesis , catalysis , political science , organic chemistry , law
The current status of organic synthesis is hampered by costly protecting‐group strategies and lengthy purification procedures after each synthetic step. To circumvent these problems, the synthetic potential of multicomponent domino reactions has been utilized for the efficient and stereoselective construction of complex molecules from simple precursors in a single process. In particular, domino reactions mediated by organocatalysts are in a way biomimetic, as this principle is used very efficiently in the biosynthesis of complex natural products starting from simple precursors. In this Minireview, we discuss the current development of this fast‐growing field.