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Selective Platination of Modified Oligonucleotides and Duplex Cross‐Links
Author(s) -
Algueró Berta,
López de la Osa Jaime,
González Carlos,
Pedroso Enrique,
Marchán Vicente,
Grandas Anna
Publication year - 2006
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200603128
Subject(s) - oligonucleotide , duplex (building) , thioether , chemistry , combinatorial chemistry , stereochemistry , computational biology , computer science , biochemistry , gene , biology , dna
Stabilizing strands : Selectively cross‐linked duplexes can be obtained either by hybridization‐promoted rearrangement of platinated oligonucleotides or by annealing thioether‐ and imidazole‐modified oligonucleotides and their complementary chains in the presence of transplatin (see structure).