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Site‐Specific DNA Cleavage on a Solid Support: A Method for Mismatch Detection
Author(s) -
Thoeni Sandra,
Kressierer Christoph J.,
Giese Bernd
Publication year - 2007
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200603092
Subject(s) - cleavage (geology) , dna , computer science , computational biology , chemistry , biology , biochemistry , paleontology , fracture (geology)
Game, set, and mismatch : In a new method for the detection of base‐pair mismatches, an immobilized DNA strand with a cleavage site (black square) and a detection tag (red circle) is hybridized with the target strand. If the target nucleotide has a mismatch, then the marker is released from the solid phase (see scheme).
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