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General Preparation of Primary, Secondary, and Tertiary Aryl Amines by the Oxidative Coupling of Polyfunctional Aryl and Heteroaryl Amidocuprates
Author(s) -
del Amo Vicente,
Dubbaka Srinivas Reddy,
Krasovskiy Arkady,
Knochel Paul
Publication year - 2006
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200603089
Subject(s) - aryl , chloranil , amination , oxidative phosphorylation , steric effects , chemistry , primary (astronomy) , oxidative coupling of methane , cyclic amines , organic chemistry , combinatorial chemistry , medicinal chemistry , amine gas treating , catalysis , biochemistry , alkyl , physics , astronomy
A tolerant reaction : Functionalized tertiary amines have been prepared by the oxidative coupling of amidocuprates with chloranil used as the oxidant (see Scheme). A high tolerance of functional groups and insensitivity to steric hindrance characterize this general amination reaction.