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De Novo Design and Synthesis of Helix–Turn–Helix Structure from Short and Robust Mixed Helices Derived from C‐Linked Carbo‐β‐Amino Acids
Author(s) -
Sharma Gangavaram V. M.,
Subash Velaparthi,
Narsimulu Kongari,
Sankar Ampapathi Ravi,
Kunwar Ajit C.
Publication year - 2006
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200603084
Subject(s) - foldamer , helix (gastropod) , turn (biochemistry) , amino acid , triple helix , chemistry , helix turn helix , stereochemistry , biology , biochemistry , gene , dna binding protein , transcription factor , ecology , snail
In a twist : Tethering of short peptides with robust 10/12‐mixed helices, derived from C‐linked carbo‐β‐amino acids, to the turn‐inducing motif, β‐hGly‐ D ‐Pro‐Gly‐β‐hGly, permitted a de novo design of the helix–turn–helix motif in the foldamer domain.