De Novo Design and Synthesis of Helix–Turn–Helix Structure from Short and Robust Mixed Helices Derived from C‐Linked Carbo‐β‐Amino Acids | Zendy

Sharma Gangavaram V. M. | Zendy; Subash Velaparthi | Zendy; Narsimulu Kongari | Zendy; Sankar Ampapathi Ravi | Zendy; Kunwar Ajit C. | Zendy

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De Novo Design and Synthesis of Helix–Turn–Helix Structure from Short and Robust Mixed Helices Derived from C‐Linked Carbo‐β‐Amino Acids

Author(s) -

Sharma Gangavaram V. M.,

Subash Velaparthi,

Narsimulu Kongari,

Sankar Ampapathi Ravi,

Kunwar Ajit C.

Publication year - 2006

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.200603084

Subject(s) - foldamer , helix (gastropod) , turn (biochemistry) , amino acid , triple helix , chemistry , helix turn helix , stereochemistry , biology , biochemistry , gene , dna binding protein , transcription factor , ecology , snail

In a twist : Tethering of short peptides with robust 10/12‐mixed helices, derived from C‐linked carbo‐β‐amino acids, to the turn‐inducing motif, β‐hGly‐ D ‐Pro‐Gly‐β‐hGly, permitted a de novo design of the helix–turn–helix motif in the foldamer domain.

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