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Regio‐ and Chemoselective Enzymatic N‐Oxygenation In Vivo, In Vitro, and in Flow
Author(s) -
Winkler Robert,
Richter Martin E. A.,
Knüpfer Uwe,
Merten Dirk,
Hertweck Christian
Publication year - 2006
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200603060
Subject(s) - in vivo , regioselectivity , oxygenation , chemistry , in vitro , enzyme , hydrogen peroxide , combinatorial chemistry , biochemistry , catalysis , medicine , biology , microbiology and biotechnology
Action by the para : Evaluation of the nitro‐group‐forming N‐oxygenase AurF in vivo, in vitro, and immobilized as a fusion protein with simply H 2 O 2 as oxidant (peroxide shunt) reveals para ‐regioselective oxygenation of aromatic amines (see scheme). This effect includes the selective oxygenation of diamino compounds.