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Intermolecular Oxidative Enolate Heterocoupling
Author(s) -
Baran Phil S.,
DeMartino Michael P.
Publication year - 2006
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200603024
Subject(s) - intermolecular force , oxidative phosphorylation , chemistry , computational chemistry , organic chemistry , molecule , biochemistry
No priming necessary : The intermolecular oxidative heterocoupling of imides and oxindoles to esters, ketones, and lactones is shown for the first time to be synthetically viable. Strategic use of the initial oxidation state of the reactants allows for the excision of prefunctionalization steps (halogenation, enol‐silane formation) and allows for the concise synthesis of unsymmetrical lignans, such as (−)‐bursehernin ( 1 ).