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Diarylprolinol Ethers: Expanding the Potential of Enamine/Iminium‐Ion Catalysis
Author(s) -
Palomo Claudio,
Mielgo Antonia
Publication year - 2006
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200602943
Subject(s) - iminium , enamine , chemistry , electrophile , steric effects , organocatalysis , nucleophile , catalysis , organic chemistry , combinatorial chemistry , computational chemistry , enantioselective synthesis
Organocatalysts based on diarylprolinol ethers mediate a broad range of reactions involving enamine or iminium‐ion activation or a combination of both. The reactions are characterized by efficient steric control of the approach of the respective electrophile/nucleophile to the enamine/iminium‐ion counterpart, thus complementing reactions involving hydrogen‐bond donors as directing key elements.