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Diversity in Guanine‐Selective DNA Binding Modes for an Organometallic Ruthenium Arene Complex
Author(s) -
Liu HongKe,
BernersPrice Susan J.,
Wang Fuyi,
Parkinson John A.,
Xu Jingjing,
Bella Juraj,
Sadler Peter J.
Publication year - 2006
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200602873
Subject(s) - ruthenium , chemistry , guanine , stereochemistry , dna , group 2 organometallic chemistry , ethylenediamine , ligand (biochemistry) , combinatorial chemistry , ring (chemistry) , molecule , organic chemistry , biochemistry , receptor , nucleotide , gene , catalysis
Seek and hide! An organometallic ruthenium arene anticancer complex with ruthenium (pink ball) chelated by ethylenediamine (blue) is selective for guanine bases on DNA and can bury the noncoordinated phenyl ring of its arene ligand (yellow) between bases in the double helix.