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Total Synthesis of Paliurine F
Author(s) -
Toumi Mathieu,
Couty François,
Evano Gwilherm
Publication year - 2007
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200602865
Subject(s) - aryl , key (lock) , linkage (software) , chemistry , ether , computer science , combinatorial chemistry , stereochemistry , organic chemistry , biochemistry , alkyl , computer security , gene
A couple of coppers : An efficient, asymmetric synthesis of the sedative cyclopeptide alkaloid paliurine F has been achieved. The strategy employs two copper(I)‐mediated coupling reactions as key steps to install the aryl ether linkage as well as to form the enamide with a concomitant unprecedented macrocyclization.