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Total Synthesis of Antibiotics GE2270A and GE2270T
Author(s) -
Nicolaou K. C.,
Zou Bin,
Dethe Dattatraya H.,
Li Dong Bo,
Chen David Y.K.
Publication year - 2006
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200602798
Subject(s) - regioselectivity , stereochemistry , antibiotics , total synthesis , chemistry , pyridine , organic chemistry , biochemistry , catalysis
Beat the bugs : Total syntheses of the thiopeptide antibiotics GE2270A (XY=CH 2 CH) and GE2270T (XY=CHC) have been accomplished. The modular approach featured a hetero‐Diels–Alder dimerization (A) to construct the trithiazolyl pyridine domain, and highly regioselective macrolactamizations (B) to furnish the macrocyclic core.