Degradable Polyelectrolyte Capsules Filled with Oligonucleotide Sequences | Zendy

Zelikin Alexander N. | Zendy; Li Qi | Zendy; Caruso Frank | Zendy

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Degradable Polyelectrolyte Capsules Filled with Oligonucleotide Sequences

Author(s) -

Zelikin Alexander N.,

Li Qi,

Caruso Frank

Publication year - 2006

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.200602779

Subject(s) - dispersity , oligonucleotide , polyelectrolyte , dna , capsule , chemistry , chemical engineering , polymer science , nanotechnology , materials science , polymer chemistry , polymer , biochemistry , organic chemistry , biology , engineering , botany

To cap it all : A polycation‐free encapsulation method is used to obtain high concentrations of uncomplexed, short oligonucleotide chains confined within monodisperse, degradable microcapsules. Oligonucleotide loadings of >10 4 chains per capsule are obtained, and more than 90 % of the capsules are filled with DNA. These capsules also undergo degradation under reducing conditions (such as those that occur in cells), releasing the encapsulated DNA.

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