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Degradable Polyelectrolyte Capsules Filled with Oligonucleotide Sequences
Author(s) -
Zelikin Alexander N.,
Li Qi,
Caruso Frank
Publication year - 2006
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200602779
Subject(s) - dispersity , oligonucleotide , polyelectrolyte , dna , capsule , chemistry , chemical engineering , polymer science , nanotechnology , materials science , polymer chemistry , polymer , biochemistry , organic chemistry , biology , engineering , botany
To cap it all : A polycation‐free encapsulation method is used to obtain high concentrations of uncomplexed, short oligonucleotide chains confined within monodisperse, degradable microcapsules. Oligonucleotide loadings of >10 4 chains per capsule are obtained, and more than 90 % of the capsules are filled with DNA. These capsules also undergo degradation under reducing conditions (such as those that occur in cells), releasing the encapsulated DNA.