Palladium‐Catalyzed Cross‐Coupling Reactions of Diazine  N ‐Oxides with Aryl Chlorides, Bromides, and Iodides | Zendy

Leclerc JeanPhilippe | Zendy; Fagnou Keith | Zendy

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Palladium‐Catalyzed Cross‐Coupling Reactions of Diazine N ‐Oxides with Aryl Chlorides, Bromides, and Iodides

Author(s) -

Leclerc JeanPhilippe,

Fagnou Keith

Publication year - 2006

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.200602773

Subject(s) - diazine , palladium , aryl , pyrazine , pyridazine , catalysis , chemistry , yield (engineering) , pyrimidine , oxide , coupling reaction , organic chemistry , medicinal chemistry , materials science , stereochemistry , alkyl , metallurgy

New aspects of N ‐oxides : Pyrazine, pyridazine, and pyrimidine N ‐oxides are regioselectively arylated with aryl iodides, bromides, and chlorides in the presence of a palladium catalyst (see scheme). The resulting products can be deoxygenated in high yield or further functionalized by making use of the N ‐oxide functionality. FG=functional group.

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