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Palladium‐Catalyzed Cross‐Coupling Reactions of Diazine N ‐Oxides with Aryl Chlorides, Bromides, and Iodides
Author(s) -
Leclerc JeanPhilippe,
Fagnou Keith
Publication year - 2006
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200602773
Subject(s) - diazine , palladium , aryl , pyrazine , pyridazine , catalysis , chemistry , yield (engineering) , pyrimidine , oxide , coupling reaction , organic chemistry , medicinal chemistry , materials science , stereochemistry , alkyl , metallurgy
New aspects of N ‐oxides : Pyrazine, pyridazine, and pyrimidine N ‐oxides are regioselectively arylated with aryl iodides, bromides, and chlorides in the presence of a palladium catalyst (see scheme). The resulting products can be deoxygenated in high yield or further functionalized by making use of the N ‐oxide functionality. FG=functional group.