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Synthesis of the C31–C67 Fragment of Amphidinol 3
Author(s) -
de Vicente Javier,
Huckins John R.,
Rychnovsky Scott D.
Publication year - 2006
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200602742
Subject(s) - tetrahydropyran , fragment (logic) , polyene , medicine , stereochemistry , computer science , algorithm , organic chemistry , chemistry , ring (chemistry)
A tetrahydropyran intermediate , prepared from (−)‐diethyl tartrate, was used to assemble the C31–C67 fragment of amphidinol 3. Both of the tetrahydropyran rings in the natural product were prepared from this intermediate. The polyene segment was assembled with high selectivity.