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Diels–Alder Approach to Polysubstituted Biaryls: Rapid Entry to Tri‐ and Tetra‐ ortho ‐substituted Phosphorus‐Containing Biaryls
Author(s) -
Ashburn Bradley O.,
Carter Rich G.
Publication year - 2006
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200602683
Subject(s) - palladium , chemistry , tetra , phosphine , phosphine oxide , ligand (biochemistry) , diels–alder reaction , nitro , combinatorial chemistry , phosphorus , organic chemistry , catalysis , medicinal chemistry , receptor , biochemistry , alkyl
Rapid construction : A Diels–Alder‐based approach to the synthesis of highly functionalized biaryls from readily available precursors is disclosed. The utility of these biaryl templates in palladium‐mediated couplings is explored along with subsequent reductions of the nitro and phosphine oxide moieties. Finally, initial application of a synthesized biaryl as a highly active ligand in palladium‐mediated coupling is carried out.