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Tamiflu: The Supply Problem
Author(s) -
Farina Vittorio,
Brown Jack D.
Publication year - 2006
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200602623
Subject(s) - neuraminidase inhibitor , pandemic , neuraminidase , shikimic acid , oseltamivir , influenza a virus subtype h5n1 , bird flu , virology , quinic acid , natural (archaeology) , covid-19 , medicine , chemistry , biology , virus , organic chemistry , disease , infectious disease (medical specialty) , paleontology , pathology
Taming of the flu : Shikimic and quinic acids are the established starting materials for Tamiflu, a viral neuraminidase inhibitor that is considered by many as the first‐line treatment against a possible H5N1 (bird flu) pandemic. Several syntheses have been described recently that circumvent the use of these natural products. These, or related approaches, may provide an alternative practical approach to this important drug.