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Saccharide‐Induced Peptide Conformation in Glycopeptides of the Recognition Region of LI‐Cadherin
Author(s) -
Kuhn Axel,
Kunz Horst
Publication year - 2007
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200602494
Subject(s) - glycopeptide , chemistry , peptide , cadherin , glycoprotein , adhesion , biochemistry , stereochemistry , cell , organic chemistry , antibiotics
The type and the size of the saccharide side chain can affect the conformation of the peptide portion of glycopeptides. This was shown by conformational analysis in solution for a series of glycoundecapeptides with systematically varied tumor‐associated carbohydrate antigens of type A from the recognition region of the cell adhesion glycoprotein LI‐cadherin (gray C, red O, blue N; the saccharide side chain is more intensely colored).