Premium
Gold(I)‐Catalyzed Intermolecular Cyclopropanation of Enynes with Alkenes: Trapping of Two Different Gold Carbenes
Author(s) -
López Salomé,
HerreroGómez Elena,
PérezGalán Patricia,
NietoOberhuber Cristina,
Echavarren Antonio M.
Publication year - 2006
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200602448
Subject(s) - cyclopropanation , intermolecular force , trapping , catalysis , chemistry , medicinal chemistry , organic chemistry , biology , molecule , ecology
Caught in a trap : Intermolecular cyclopropanation reactions of enynes with alkenes allows the synthesis of complex cyclic systems with gold(I) catalysts under mild conditions. Furthermore, gold carbenes are trapped intermolecularly with alkenes (see scheme; L=ligand), thereby providing experimental evidence for the involvement of two different types of metal carbenes in the skeletal rearrangement of enynes.