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Total Syntheses of the Antibacterial Natural Product Abyssomicin C
Author(s) -
Peters René,
Fischer Daniel F.
Publication year - 2006
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200602409
Subject(s) - polyketide , natural product , intermolecular force , bacteria , stereochemistry , pathogenic bacteria , total synthesis , chemistry , antibacterial activity , combinatorial chemistry , biology , organic chemistry , molecule , biosynthesis , genetics , enzyme
Intra‐ or intermolecular : Abyssomicin C, isolated from a marine bacterium, is a potent polyketide‐type antibiotic and a synthetic target of prime importance because it inhibits pathogenic bacteria. In recent independent syntheses by the Sorensen and the Nicolaou groups, intra‐ and intermolecular Diels–Alder reactions featured as the respective key steps for the construction of the oxabicyclo[2.2.2]octane core.