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An Anticoagulant with Light‐Triggered Antidote Activity
Author(s) -
Heckel Alexander,
Buff Maximilian C. R.,
Raddatz MarieSophie L.,
Müller Jens,
Pötzsch Bernd,
Mayer Günter
Publication year - 2006
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200602346
Subject(s) - antidote , aptamer , intramolecular force , irradiation , chemistry , biophysics , anticoagulant , pharmacology , photochemistry , medicine , stereochemistry , biology , toxicity , microbiology and biotechnology , physics , nuclear physics
A light remedy to overdosing : Aptamers with an intramolecular “caged” antisense region remain active until they are irradiated. Upon irradiation, the antisense activity is released and the aptamer refolds into an inactive structure (see scheme).