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Direct Monitoring of the Asymmetric Induction of Solid‐Phase Catalysis Using Circular Dichroism: Diamine–Cu I ‐Catalyzed Asymmetric Henry Reaction
Author(s) -
Arai Takayoshi,
Watanabe Masahiko,
Fujiwara Akitsugu,
Yokoyama Naota,
Yanagisawa Akira
Publication year - 2006
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200602255
Subject(s) - catalysis , diamine , circular dichroism , phase (matter) , asymmetric induction , chemistry , enantioselective synthesis , crystallography , stereochemistry , polymer chemistry , organic chemistry
The direct approach : A new high‐throughput screening system for analyzing the asymmetric induction in catalytic enantioselective synthesis couples solid‐phase reactions with a circular dichroism detection system (see picture). Thus, direct monitoring of asymmetric induction without the need for purification or chromatographic analysis is obtained.