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Rational Design of Bioorganometallic Foldamers: A Potential Model for Parallel β‐Helical Peptides
Author(s) -
Chowdhury Somenath,
Schatte Gabriele,
Kraatz HeinzBernhard
Publication year - 2006
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200602248
Subject(s) - foldamer , chemistry , ferrocene , sequence (biology) , alanine , amino acid , stereochemistry , combinatorial chemistry , biochemistry , electrode , electrochemistry
Twists and turns : A series of alanine conjugates of ferrocene amino acid (Fca) were prepared based on the idea that an alternating sequence of a natural α‐amino acid and a turn‐inducing molecule may result in the formation of a robust model foldamer for β‐helical peptides. Right‐ and left‐handed pseudo‐β‐helical Fca–alanine foldamers were obtained, and their structures were studied in solution and the solid state.